![]() ![]() 1 It consists of three types of cells: P cells, transitional cells, and Purkinje's cells. The objectives of this review are (1) to discuss the pathogenesis and pathophysiology of arrhythmias associated with sinus node dysfunction, (2) to provide a clinical, electrocardiographic, and electrophysiological basis for their diagnosis, and (3) to discuss principles of management, including the use of the cardiac electrophysiology laboratory.Īnatomy and Pathophysiology The sinus node is located in the posterior right atrial wall at the junction of the right atrium and superior vena cava. Blood testing To rule out an underlying metabolic problem. The sick sinus syndrome is a descriptive term coined by Lown (1966) and popularized by Ferrer (1968), referring to a constellation of clinical signs. These arrhythmias currently afflict more than 100,000 Americans, and as a group constitute the most common indication for permanent cardiac pacemaker implantation. An electrocardiogram (ECG)To look for abnormalities characteristic of SSS changes. The heart suddenly stops and is rescued by an escape rhythm. If atropine is not available Inject 0.01 mg/kg glycopyrrolate intravenously and then repeat the ECG after 15 minutes. OR Inject 0.04 mg/kg atropine subcutaneously and then repeat the ECG after 30 minutes. DURING the past 15 years, we have become increasingly aware of the importance of arrhythmias associated with sinus node dysfunction as a cause of cardiac and neurological symptoms. ART protocol Inject 0.04 mg/kg atropine intravenously and then repeat the ECG after 15 minutes. ![]()
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